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From San Francisco:
Take US-101 N toward 19th Ave./Golden Gate Bridge and continue north for 51 miles until you reach the Downtown Santa Rosa exit.
From Sacramento:
Take I-80 W 48 miles to CA-37 W toward San Rafael and continue on for about 20.5 miles until you reach US-101 N toward Santa Rosa/Eureka. Take US-101 N 28 miles until you reach the Downtown Santa Rosa exit.
From Sonoma:
Take Sonoma HWY (12 W) 19 miles until it runs into 4th Street/Downtown Santa Rosa.
From the East Bay:
Take I-580 W toward Richmond/Sacramento and continue across the Richmond-San Rafael Bridge for about 13 miles until you reach US-101 N. Continue north for about 37 miles until you reach the Downtown Santa Rosa exit.
From Mendocino:
Take CA-1 S for 10 miles until you reach CA-28. Continue on CA-28 for 55 miles and make a left at N Cloverdale Blvd. After .6 miles turn right onto the CA-128 E/US-101 S ramp toward San Francisco. Take US-101 S 32 miles until you reach the College Avenue exit in Santa Rosa.